On July 20th 1969, Neil Armstrong and Buzz Aldrin were flown up in a spaceship on a Moon landing mission, to collect lunar material to bring back to Earth. Whilst this took them about a day to collect about 21.5kg, they then had to go through a slightly different ordeal, when they came back down.
On the 24th of July, the astronauts returned on the Columbia Command Module in the Pacific Ocean. The parachutes to slow its descent worked perfectly, and after seven minutes of parachuting down, it hit the water. Despite landing upside down, the astronauts triggered the flotation device, which launched bags to put it the right way up again.
Then the Navy came to the Command Module, securing it in place, and stabilising it. The astronauts were still at risk of bring bank some pathogens from the surface, and whilst this was a very small chance, NASA didn’t take the risk. The astronauts were effectively in quarantine, and they had to use sodium hypochlorite to help remove any pathogens. The Command Module was then also cleaned down with Betadine, and the raft containing all these materials, was then sunk to get rid of it.
Once the helicopter landed at the Mobile Quarantine Facility, they then had to begin 21 day quarantine. It wasn’t until the 10th of August, that the astronauts could then go home to their families.
The quarantine process did continue for two more missions, but after it was decided there was no life on the Moon, there was no longer any need to worry about risk of pathogens, and so the entire quarantine process, much to the relief of astronauts, was stopped.